Job Description
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
About the Role
We are seeking a highly motivated and technically skilled Advisor to join our Gene Therapy Discovery and Platform Research (GTDPR) Analytical Development group. In this role, you will help us advance our understanding of AAV biology, develop novel analytical methods, and support progression of Lilly gene therapy pipeline. We are looking for an enthusiastic, curious, self-motivated, and hands-on candidate with excellent interpersonal skills who is comfortable working in an open, highly collaborative, and fast-paced environment.
Key Responsibilities
Develop gene therapy and gene editing expression and mechanism-of-action potency assays for various pipeline programs.
Lead viral protein characterization using CE-SDS (Sciex PA800, BioPhase 8800, LabChip) and SDS-PAGE to support AAV VP ratio and capsid purity quality assessments.
Contribute to AAV vector design including capsid and Rep protein modifications, such as rational capsid engineering and Rep functional optimization to advance gene therapy delivery, improve AAV replication/packaging, and manufacturing outcomes.
Provide analytical support to vector core group through cell-based, CE-SDS, and other compendial analytical testing.
Collaborate cross-functionally with analytical, process development, discovery, and translational teams to advance research projects and pipeline programs forward.
Assist in expanding our analytical capabilities by developing novel methods to investigate new quality attributes, and improve throughput or efficiency.
Effectively coach junior scientists to develop their critical thinking and technical skills.
Basic Requirement
PhD with 1+ years, MS with 7+ years, or BS with 12+ years of relevant industry experience with a degree in a scientific field (cell biology, molecular biology, virology, biochemistry, biomedical engineering).
Additional Skills and Preferred Qualifications
Demonstrated expertise with a broad range of cellular and molecular biology techniques (e.g ddPCR, qPCR, CE-SDS, ELISA, MSD, primer design, western blot, adherent and suspension mammalian cell culture, plasmid transfection, lentivirus transduction, stable cell-line development).
Proficiency in flow cytometry (transduction efficiency, surface marker phenotyping) and high-content imaging platforms (e.g., Operetta) for cell-based assay development and analysis.
Demonstrated experience in AAV vector design, engineering, and characterization, including use of molecular cloning tools (e.g., SnapGene, Benchling) for construct design, capsid modification, and genome cassette optimization.
Proficiency in analytical data analysis (e.g. GraphPad Prism, Rstudio), interpretation, and scientific documentation (Benching lab notebooks, technical reports, SOPs) as well as scientific communication.
Strong cross-functional collaboration and communication skills.
Ability to independently learn new techniques and develop novel methods with minimal prior experience.
Additional Information
Location: Lilly Harborside Laboratories, Seaport District, Boston, Massachusetts
Position requires on-site presence, 8-hour days, five days per week
0-10% travel
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $224,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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