(Sr.) Manager, Clinical Supply Chain

Centessa Pharmaceuticals plc (Nasdaq: CNTA) new kind of pharmaceutical company with a deconstructed R&D environment that prioritizes data driven decision making led by subject matter experts. Centessa is advancing a portfolio of high conviction programs with strong biological validation. Our asset-centric model offers a unique R&D logic that has been applied by single asset companies to improve productivity. This operating model has minimal centralized infrastructure, reduced hierarchy, and exclusive focus on data driven capital allocation. Our teams are uniquely incentivized to expeditiously interrogate key scientific hypotheses. We believe the asset-centric model can lead to improved success rates for programs with greater speed and modest costs. Description of Role Centessa is seeking a (Sr.) Manager, Clinical Supply Chain to oversee end-to-end planning, execution, and maintenance of uninterrupted clinical supply, including IP, comparators, and ancillary materials. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and ensure successful trial execution. Key responsibilities include managing clinical forecasts, inventory systems, and IRT tools with strong attention to detail and daily operational oversight. Key Responsibilities Clinical Supply Planning & Execution: Lead development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable). Own clinical supply plans, demand forecasts, and inventory strategies aligned with protocol requirements and enrollment projections. Manage packaging, labeling, distribution, and resupply activities for investigational products and comparators. Ensure on-time delivery of clinical supplies to depots and clinical sites globally. Vendor & External Partner Management: Collaborate with Quality, Clinical, CMC and external CDMOs to develop and approve clinical labels. Manage CDMO packaging/labeling schedules to ensure availability of clinical supplies. Interact regularly with third-party providers to manage logistics & licenses required to ship materials from manufacturing to bulk storage facilities, courier depots and investigator sites. Work with CMC and QA to facilitate document transfer required for CTM/QP release by CDMOs Manage and track clinical supply inventory either manually or through an Interactive Response Technology (IRT) system. Manage Product Recovery pending investigation of CTM from investigator sites as needed. Collaboration: Effectively collaborate and communicate across multiple functional areas, bringing a sufficient breadth of knowledge. Monitor shelf-life and expiry dating and coordinate retest extension with analytical team to ensure continuous supply. Manage investigation, reporting and communication of outcomes from temperature excursions and product complaints. Author Pharmacy Manuals for clinical studies, as needed Represent Supply Chain in Clinical and CMC Sub Team meetings Qualifications Bachelor’s degree in engineering or science is required. 5-8 years of biotech/pharma industry experience in clinical supply with international experience is required Experience in all aspects of clinical supply chain as well as a deep understanding of GMP/GDP Requires a strong understanding of managing groups, CMOs and CDMOs Experience with blistering and walleting packaging processes preferred Proven background in working with small molecule modality required Experience operating within a commercial drug product environment preferred Strong organizational, analytical, decision-making and interpersonal skills Ability to work independently in a fast-paced dynamic environment Demonstrated ability to coordinate CDMO activities in the development and commercialization of pharmaceutical products Excellent organizational skills, project management skills and detail-orientated leadership approach Ability to thrive in a small company culture and assist in creating and implementing processes. Compensation The annual base salary range for the Manager, Supply Chain position is $120,000 - $157,000.  The annual base salary range for the Senior Manager, Supply Chain position is $145,000 - $190,000. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge. In addition to base pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to share in Centessa’s long-term success. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. Work Location The (Sr.) Manager, Clinical Supply Chain role is a remote role based in the US, with occasional travel (up to 20%). POSITION: Full-Time, Exempt EEOC Statement: Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.