Director, Scientific Operations

About Glyphic: At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you Glyphic is seeking a scientifically rigorous, pragmatic, and execution-driven leader for a Director of Scientific Operations, reporting to the VP of R&D. The Director of Scientific Operations will own the preparation, stabilization, and management of evaluation-grade reagents and scientific operations that enable reliable execution of our single-molecule protein sequencing platform. This role works closely with the Director of Chemistry and the Director of Assay Development to translate novel chemical components and reagents into stockable, assay-ready units, and to collaboratively understand which reagent attributes are most important for assay performance. This is a hands-on leadership role focused on scientific judgment, speed, and reproducibility in an early-stage R&D environment. Characterization is intentionally fit-for-purpose and evolves alongside assay understanding. The ideal candidate brings strong operational and scientific judgment, clearly distinguishing which reagent attributes matter—and which do not—for assay performance, while building fit-for-purpose operational frameworks that enable chemistry inventions to be translated into usable, reproducible reagents without unnecessary delay or over-characterization. This role offers a unique opportunity to define and lead scientific operations at a formative stage, ensuring reagent knowledge, operational infrastructure, and assay understanding evolve in lockstep to support the company’s next-generation protein sequencing platform. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location. What you’ll do Reagent Preparation & Stocking Prepare, formulate, stabilize, and stock evaluation‑grade reagents and buffers required for sequencing assays Establish storage conditions, handling practices, and refresh strategies that preserve assay‑relevant performance Design and run fit‑for‑purpose stability studies to understand how reagents change over time and under different conditions Produce and manage reagent and assay‑ready consumable inventories sufficient to support ongoing experiments, demos, and early evaluations Collaborative Characterization & Understanding Work with Chemistry and Assay teams to identify which reagent attributes matter most for assay performance (e.g., purity, activity, labeling efficiency, degradation modes) Perform and coordinate targeted, hypothesis‑driven characterization to inform assay interpretation and reagent handling Translate experimental observations into practical guidance for reagent preparation, storage, and use Avoid premature or exhaustive characterization that does not inform assay performance Cross‑Functional Enablement Partner closely with the Director of Chemistry to understand chemical design intent and expected behavior Partner closely with the Director of Assay Development to ensure reagents meet assay needs and constraints Translate chemistry prototypes into repeatable, reproducible reagent preparation workflows Identify sources of reagent variability and drive scientific root‑cause analysis in collaboration with chemistry and assay teams Infrastructure, Facilities & Process Develop lightweight documentation for reagent preparation, stabilization, storage, and usage; translate R&D protocols into fit-for-purpose SOPs as needed Build and maintain lab infrastructure required for reagent preparation and storage Oversee facilities operations as they relate to R&D, serving as the connective tissue between scientific operations and facilities Negotiate terms and manage relationships with vendors and service providers; ensure consumables, equipment, lab spaces, and utilities support evolving R&D needs Serve as the scientific owner for reagent readiness prior to any future manufacturing transition Ensure equipment functionality, inventory and supply management, safety compliance, and other logistical functions of a research laboratory Team & Lab Operations Lead and mentor a small team (approximately 2 people) supporting reagent preparation and general lab stocking Oversee day‑to‑day lab readiness, including consumables, buffers, and shared reagent availability Establish lightweight processes to keep the lab running smoothly without over‑engineering What you need Required: BS/MS degree in Chemistry, Chemical Biology, Biochemistry, Engineering, or a related discipline 7–10+ years of relevant industry experience supporting R&D teams in scientific operations Proven experience managing reagent inventory, forecasting demand, and preventing stock-outs for active R&D programs Deep hands-on experience with reagent preparation, formulation, stabilization, and fit-for-purpose characterization, including translating R&D protocols into usable SOPs Familiarity with sequencing or broader omics workflows, including custom reagents, consumables, and specialized equipment Demonstrated people-leadership experience, including supervising staff and reporting forecasts, plans, and risks to management Strong negotiation skills with external vendors, including securing favorable contract terms, pricing, and supply agreements Experience collaborating with procurement and accounting functions (e.g., forecasting inputs, hand-offs to AP) Excellent cross-functional communication skills and comfort coordinating across Chemistry, Assay Development, Operations, and Facilities Nice to have: Demonstrated ability to proactively identify and resolve emerging scientific or operational issues before they impact assay execution or timelines Comfort operating in early-stage environments with minimal structure and evolving priorities We’re looking for teammates with: Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels. High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic. Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity. Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences. What you can expect from this role Work environment: Collaborative culture where your ideas and expertise are valued Direct impact on product development and company direction Professional growth: Opportunity to build and scale a high-impact scientific operations function. Learn from a diverse team of world-class scientists and engineers Compensation Estimated Base Salary $166,050 - $201,925 This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas. Benefits and Perks: Employee Stock Option Plan 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision) Employer Retirement Contributions to 401(k) Generous Paid Time Off Paid Maternity and Paternity Leave Health & Wellbeing Program Office Snacks and Beverages Regular Team Bonding Activities We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.