Oligonucleotide Chemistry, Co-Op

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook. Role Summary: Dyne is seeking a co-op for the Oligonucleotide Chemistry team who is passionate about research and excited to participate in finding cures for rare diseases with unmet needs. This Co-Op will focus on RNA therapeutics at the intersection of chemistry and biology, with a particular emphasis on synthesizing oligonucleotides (short DNA and RNA analogs) able to turn off the expression of disease-causing genes. This work will help us enhance our growing pipeline driving innovation and accelerating development of new therapies. The Oligonucleotide Chemistry team falls within the broader Platform Development team and cultivates an environment of versatility and transparency, therefore excellent communication skills are required. The Co-Op will learn key aspects of RNA therapeutics and to chemically synthesize and characterize oligonucleotides to support research in this emerging field. This role is based in Waltham, MA without the possibility of being remote. This is a 6-month position beginning in July. Candidates must be enrolled in an accredited college or university Co-Op Program. Primary Responsibilities Include: Perform solid phase synthesis of chemically modified oligonucleotides at various scales to support in vitro and in vivo experiments. Perform purification of oligonucleotides to achieve high purity standards. Perform analysis (HPLC/UPLC), and characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates. Multi-task across several projects. Gather data, create compelling slides, and present findings in group meetings. Eagerness to learn key aspects of RNA therapeutics and to synthesize oligonucleotides to support this research. Education and Skills Requirements: Currently enrolled in a Bachelors, Masters, or PhD program in Biochemistry, Organic Chemistry or related fields. Prior lab experience highly Background/coursework in chemistry, biochemistry, organic chemistry, and analytical chemistry required. General knowledge of DNA/RNA structure and function is a plus but not required. Knowledge of software applications using Microsoft Office Skills (PowerPoint, Word, Excel). Strong communication skills and willingness to collaborate with team. MA Pay Range $25—$25 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.