Principal Scientist, Chemistry Lead

The Opportunity: Does delivering a great small molecule development candidate thrill you? We get excited, too, and we are building the best environment in the industry to discover the next generation of innovative therapeutics that will make a difference for patients. We are looking for a self-motivated, experienced Medicinal Chemist to join our team. You will work on exciting targets alongside some of the most talented scientists in a highly collaborative environment, while continuing to grow into better drug hunter. Your Role: You will be responsible for developing and executing medicinal chemistry strategies on a lead optimization program to deliver a high-quality development candidate in a fast-paced environment. You will lead chemists at Relay as well as CRO teams to advance your project. You will work closely and collaboratively in a multi-disciplinary team of computational chemists, biophysicists, cell and molecular biologists, pharmacologists, and DMPK specialists. You will see how all the aspects of compound performance are necessary to make it a drug, and you can communicate that effectively to your discovery partners. Your background: PhD with at least 7 years or MS with at least 10 years of relevant biotech and/or pharmaceutical industry experience in medicinal chemistry, with an emphasis on lead optimization in small molecule drug discovery You were educated in chemistry with an emphasis on synthetic organic chemistry, synthetic methodology or a related field. You are passionate about working on high impact targets and bringing medicines to patients. You have led or are ready to lead a team and make critical decisions on the SAR direction. You have participated in the delivery of development candidates and your track record of excellence is supported by high impact, peer-reviewed publications and/or patents. You have good understanding of biology, pharmacology, DMPK and safety. You are comfortable enabling your compound design with in silico predictive tools and structure-based drug design. You have strong communication skills, can flex to different work styles, and believe that the best outcomes result from bringing out the creativity of your colleagues. You are committed to building an energetic, collaborative and open company culture and contributing to the company’s success. Estimated Salary Range: [$115,000 - $188,000]. The range provided above is based on what we believe to be a reasonable estimate for this job at the time of posting. Actual base salary will depend on a number of factors, including but not limited to, a candidate’s education, experience, skills and location. #BP1 About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you’re excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!