RA/SRA Cell Therapy Process Development (Contractor)

About Us… Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our cytoDRiVE® technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in clinical development for the treatment of patients with metastatic melanoma and non-small cell lung cancer. We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options. Our Opportunity… We are looking for a highly motivated Process Development Research Associate/Sr. Research Associate (Contractor), with a background in process development and/or characterization. You will support our process characterization efforts with engineered T-cells, helping to drive the development of our first clinical stage autologous cell therapy program targeting solid tumors. You will be a vital part of a highly collaborative team working to achieve Obsidian’s vision by collaboratively translating innovative science into medical breakthroughs for patients starting with our lead program OBX-115, a novel engineered tumor-infiltrating lymphocyte (TIL) therapy. This is a unique opportunity to be a contributor in a well-funded clinical company with blue chip investors, field-leading advisors, best-in-class partners, and an experienced team. You'll help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need. This is a lab-based role; work is full-time on-site in our Bedford, MA location. You will… Execute carefully planned process characterization experiments with engineered T-cells to support control strategy development. Support development studies as needed. Discuss data, troubleshoot technical hurdles, and communicate findings/present results at internal meetings. Carefully document data in an electronic lab notebook. Support data verification to ensure data integrity of characterization study data in eLNs and reports. Collaborate effectively with the PD and AD teams to ensure successful completion of studies and testing. Maintain a safe work environment in accordance with policies, procedures, and regulations. You bring… Core Qualifications BS degree in chemical engineering, biochemical engineering, biology or relevant field; prior Process Development experience in a biotech setting highly preferred. Experience with cell culture techniques, preferably T-cell (or other immune cells). Scientifically rigorous in executing experiments and record keeping.  Excellent planning, coordination, and time management skills  Excellent oral, written, and visual communication skills. You listen to understand and communicate effectively and persuasively with partners, colleagues, and leadership.  Ability to build and maintain productive relationships with department management, peers, and other colleagues across the organization Collaborative and accountable – recognizes success requires teamwork and interdisciplinary thinking; shares feedback and ideas to facilitate better outcomes Self-motivated, with a proven ability to meet objectives and timelines, managing multiple responsibilities in parallel. Flexible - adapts to change in a fast paced, rapidly developing environment Curious and humble – seeks and welcomes input/expertise of others, continuous learner Tenacious and resilient – is not easily overwhelmed by challenges, delivers on commitments Bonus Qualifications Experience with design of experiment (DOE) approaches and statistical analysis of data; familiarity with JMP is desirable. Basic knowledge of immunology and experience working with immune system cells. Experience with culture of mammalian cells in small -scale and large-scale bioreactor systems (e.g. G-Rex, Xuri) and associated control strategies. Experience with analytical methods for cell characterization such as flow cytometry, quantitative PCR. Obsidian is committed to equitable and transparent pay practices. The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role’s location. Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long-term incentives in the form of employee stock options, both of which are commensurate with the role’s level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities. Anticipated Base Salary Range $35—$49 USD Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.