Scientist – Cardiometabolic Disorders (Discovery)

Career Category Clinical Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist Cardiometabolic Disorders (Discovery) A Scientist at Amgen is responsible for designing and conducting experiments, analyzing results, and interpreting data. They prepare technical reports, summaries, and protocols and present study results at team meetings. They also assist in maintaining lab equipment, troubleshooting issues, and ensuring safety protocols are adhered to. What you will do Let’s do this. Let’s change the world. In this vital role you will join our Cardiometabolic Disorders team in Thousand Oaks, California to uncover novel target and disease mechanisms and advance therapeutic programs. The team focuses on developing therapeutics and elucidating disease biology for some of the most debilitating cardiometabolic disorders plaguing society. The individual will join a team of dedicated scientists committed to finding cures for these diseases to help patients. A well-suited applicant will have great molecular and cell biology laboratory skills, deep scientific curiosity, and  strong interpersonal and communication skills to thrive in a collaborative environment. The successful candidate will be responsible for the development, optimization, and implementation of in vitro and ex vivo mechanism-of-action and therapeutic validation studies that advance Amgen’s cardiometabolic disorders early pipeline. This is a permanent role that offers potential for advancement and career development. If you have a passion for science and want to be part of an organization discovering new medicines that will impact patients’ lives, we invite you to join us! Conduct laboratory-based experiments to deepen our understanding of cardiometabolic disease biology. Develop and implement assays to evaluate potential therapeutics to advance the pre-clinical pipeline. Use of laboratory techniques such as: cell culture (including primary cells), transfection and lentiviral transduction, CRISPR-based cell line engineering, ELISA, immunofluorescence and live cell imaging, SDS-PAGE and immunoblotting, molecular biology techniques including RNA and protein analysis. Organize, analyze, critically interpret, and properly document experimental design and data. Present research findings effectively in both written and oral formats for internal teams and external collaborators. Keep up to date on current literature and knowledge in the field to apply to experimental design and analysis. What we expect of you We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a highly motivated professional with these qualifications. Basic Qualifications: Doctorate Degree (PhD) or Master’s Degree with 3+ years of experience or Bachelor’s Degree with 5+ years of experience. Preferred Qualifications: Demonstrated expertise in molecular and cell biology laboratory techniques, especially as they pertain to cardiometabolic disease biology. Expertise working with both immortalized cell lines and primary cells. Extensive experience in cell-based, molecular and biochemical techniques, including live cell imaging and image processing, RNA isolation/qPCR, protein immunoprecipitation, immunoblotting, ELISA and flow cytometry. Hands-on expertise with cell line engineering technologies, including CRISPR and lentivirus-based stable cell line generation. Demonstrated experience analyzing and interpreting complex datasets. Excellent written and oral communication skills. A strong record of high-impact publications in this field. Demonstrated ability to prioritize tasks and efficiently manage multiple projects. Ability to work independently, problem-solve, and meet deadlines in a collaborative environment. What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. . Salary Range 115,393.45USD -156,120.55 USD